Part A Synthesis and Conformational Studies of Linear Peptides of Pyrrole Amino Acid. Biological activities of Peptides and proteins depend on their three dimensional structures
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چکیده
i The thesis entitled “Uses of Pyrrole Amino Acid based Scaffolds in Peptidomimetics and Studies Directed Towards the Total Synthesis of Antascomicin A”, consists of three chapters: CHAPTER I: Deals with the synthesis and conformational studies of pyrrole amino acid based peptidomimetics. This chapter is divided into two parts: Part A: Describes the synthesis and conformational studies of linear peptides of pyrrole amino acid. Part B: Describes the synthesis and structural studies of pyrrole amino acid containing peptides. CHAPTER II: Delineates the synthesis and DNA binding properties of pyrrole amino acid containing peptides. CHAPTER III: Describes the Studies Directed Towards the Total Synthesis of Antascomicin A. CHAPTER I Part A Synthesis and Conformational Studies of Linear Peptides of Pyrrole Amino Acid. Biological activities of Peptides and proteins depend on their three dimensional structures in the free state and when interacting with their receptors/acceptors. The search for relationships between structure and activity has been the principal subject for designing the selective drugs with no side effects. Initial efforts at finding a connection
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